Graham van Aggelen

Head - Environmental Toxicology Laboratory; Management of the aquatic toxicological staff and toxicological science conducted in the laboratory

Pacific Environmental Science Centre (Vancouver, BC)

CURRENT S&T / RESEARCH - Delivery of aquatic toxicological services to the Water Science and Technology Directorate and the Enforcement program

• Development of in-house toxicogenomic capacity and expertise using Salmonids; Strategic Technologies for Advancement of Genomics in Environment (STAGE)
• Toxicogenomic evaluation of emerging chemicals of concern in municipal waste water entering the Georgia basin
• Toxicogenomic evaluation of priority chemicals under Chemical Management Plan; application of toxicogenomic tools to determine potential EDC gene related profiles
• Development of in-house toxicogenomic capacity and expertise using Amphibians

KEY PUBLICATIONS

Wiseman, S., H. Osachoff, E. Bassett, J. Malhotra, J. Bruno, G. van Aggelen, T.P. Mommsen and M.M. Vijayan. 2007. Gene expression pattern in the liver during recovery from an acute stressor in rainbow trout. Comp. Biochem. Physiol. D 2(3): 234-244.

Tyler, C.R., A. Filby, T. Iguchi, V. Kramer, D.G.J. Larsson, G. van Aggelen, C. van Leeuwen, M. Viant, D. Tillitt. 2006. Application of Genomics to Tiered Testing. In: Molecular Biology and Risk Assessment: Evaluation of the Potential Roles of Genomics in Regulatory Ecotoxicology (ed. Ankley G). Society of Environmental Toxicology and Chemistry. (In press).

Wiseman, S., H. Osachoff, E. Bassett, J. Malhotra, J. Bruno, G. VanAggelen, T.P. Mommsen and M.M. Vijayan. 2007. Gene expression pattern in the liver during recovery from an acute stressor in rainbow trout. Comp. Biochem. Physiol. D (doi:10.1016/j.cbd.2007.04.005).

Crump, D., K. Werry, N. Veldhoen, G. van Aggelen and C.C. Helbing. 2002. Exposure to the herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis. Environmental Health Perspectives. 110:1199-1205.